Diisopropylethylamine → HCID 22099785, compound

HRID 1940780Notes

Reaction equation

HRID 1940780 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]([O:10][CH3:11])=[O:9])=[CH:4][CH:3]=1.C(N([CH:18]([CH3:20])[CH3:19])CC)(C)C.[CH3:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[CH2:28][C:29](Cl)=[O:30]>ClCCl.O>[CH3:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[CH2:28][C:29]([N:1]([C:29](=[O:30])[CH2:28][C:23]1[CH:22]=[CH:27][CH:26]=[CH:20][C:18]=1[CH3:19])[C:2]1[N:7]=[CH:6][C:5]([C:8]([O:10][CH3:11])=[O:9])=[CH:4][CH:3]=1)=[O:30]

Participants

6

Reactant 3

HCID 81531DiisopropylethylamineHCID 737487Methyl 6-aminonicotinateHCID 2760632o-Tolyl-acetyl chloride

Product 1

HCID 22099785HCID 22099785, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6344DichloromethaneSolvent3×

Procedure

To a chilled solution (0° C.) of 5.0 g of methyl 6-aminopyridine-3-carboxylate and 12.6 ml of diisopropylethylamine in 40 ml of dichloromethane under argon is added 12.2 g of 2-methylbenzeneacetyl chloride in 10 ml of dichloromethane. The mixture is stirred at room temperature 16 hours and diluted with 200 ml of dichloromethane and 50 ml of water. The organic layer is separated and washed with 50 ml each of 1M NaHCO3, brine and dried (Na2SO4). The solution is filtered through a thin pad of hydrous magnesium silicate and the filtrate concentrated to dryness. The residue (9.0 g) is purified by chromatography on silica gel with hexane-ethyl acetate (3:1) as eluent to give 0.70 g of methyl 6-[[bis(2-methylbenzeneacetyl)]amino]pyridine-3-carboxylate and 8.6 g of a mixture of methyl 6-[(2-methylbenzeneacetyl)amino]pyridine-3-carboxylate and the bis acylated product. The above mixture (8.6 g) of mono and bis acylated product is dissolved in 60 ml of tetrahydrofuran-methanol (1:1) and 23 ml of 5N NaOH is added. The solution is stirred at room temperature for 16 hours, concentrated under vacuum, diluted with 25 ml of H2O and acidified with cold 1N HCl. The precipitated solid is filtered off and dried to give 5.9 g of white solid.

Workup

  1. customThe organic layer is separated
  2. washwashed with 50 ml each of 1M NaHCO3, brine
  3. dry with materialdried (Na2SO4)
  4. filtrationThe solution is filtered through a thin pad of hydrous magnesium silicate
  5. concentrationthe filtrate concentrated to dryness
  6. customThe residue (9.0 g) is purified by chromatography on silica gel with hexane-ethyl acetate (3:1) as eluent

Sources & evidence

ORD record
ord-ece015ad59d84762b7cf558f15f8df20
Source dataset
uspto-grants-1997_12
Patent number
US05700796

Reaction notes

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