反应详情

Potassium hydroxide (10.6 g) was added to a suspension of 6.82 g of cysteamine hydrochloride and 10.0 g of 4-chloromethyl-2-hydroxymethylthiazolehydrochloride in 100 ml isopropanol. The resulting suspension was stirred at room temperature for 2 hours and filtered through a pad of celite to remove insoluble inorganics and concentrated under reduced pressure. The residue was taken up in dichloromethane and filtered through a pad of celite and concentrated under reduced pressure. The oil (12.54 g) represents a quantitative yield of 4-[[(2-aminoethyl)thio]methyl]-2-hydroxy-methylthiazole contaminated only with inorganic salts.

1. filtrationfiltered through a pad of celite
2. customto remove insoluble inorganics
3. concentrationconcentrated under reduced pressure
4. filtrationfiltered through a pad of celite
5. concentrationconcentrated under reduced pressure