Isopropanol → HCID 178435127, compound

HRID 1940886Notes

Reaction equation

HRID 1940886 reaction equation
[OH-:1].[K+].Cl.[NH2:4][CH2:5][CH2:6][SH:7].Cl.Cl[CH2:10][C:11]1[N:12]=[C:13](CO)[S:14][CH:15]=1.[CH:18](O)(C)C>>[NH2:4][CH2:5][CH2:6][S:7][CH2:10][C:11]1[N:12]=[C:13]([OH:1])[S:14][C:15]=1[CH3:18]

Participants

5

Reactant 4

HCID 3776IsopropanolHCID 9082Cysteamine HydrochlorideHCID 14797Potassium HydroxideHCID 21464457[4-(Chloromethyl)-1,3-thiazol-2-yl]methanol hydrochloride

Product 1

HCID 178435127HCID 178435127, compound

Procedure

Potassium hydroxide (10.6 g) was added to a suspension of 6.82 g of cysteamine hydrochloride and 10.0 g of 4-chloromethyl-2-hydroxymethylthiazolehydrochloride in 100 ml isopropanol. The resulting suspension was stirred at room temperature for 2 hours and filtered through a pad of celite to remove insoluble inorganics and concentrated under reduced pressure. The residue was taken up in dichloromethane and filtered through a pad of celite and concentrated under reduced pressure. The oil (12.54 g) represents a quantitative yield of 4-[[(2-aminoethyl)thio]methyl]-2-hydroxy-methylthiazole contaminated only with inorganic salts.

Workup

  1. filtrationfiltered through a pad of celite
  2. customto remove insoluble inorganics
  3. concentrationconcentrated under reduced pressure
  4. filtrationfiltered through a pad of celite
  5. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-66e071607a584d56b48639957c88b5e7
Source dataset
uspto-grants-1997_12
Patent number
US05700945

Reaction notes

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