Acetic Acid → Nicotinic Acid

Participants

Reaction Steps

The same autoclave as that used in Example 1 was charged with 25 parts by weight of 3-methylpyridine, 0.38 part by weight of cobalt acetate, 0.27 part by weight of manganese acetate, 1 part by weight of tetrapropylammonium bromide and 150 parts by weight of acetic acid having a 5 wt % water content, and the mixture was allowed to react in the same manner as in Example 1 to give 21.7 parts by weight of a crude nicotinic acid crystal. The conversion of the 3-methylpyridine was 93.7 mol %, the selectivity to the nicotinic acid was 99.0 mol %, and the yield of the nicotinic acid 92.8 mol %. The conversion and the yield in Example 2 were improved over those in Example 1 since the solvent was used in a larger amount in Example 2. The crude nicotinic acid had a bromine concentration of 608 ppm and showed a dissolved b value of 5.44.

Provenance & Evidence