2-(6-Methoxy-2-naphthyl)propionic acid → 2-(6-methoxynaphthalen-2-yl)propanoyl Chloride

HRID 1940890Notes

Reaction equation

HRID 1940890 reaction equation
S(Cl)([Cl:3])=O.[CH3:5][O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[CH:13]=[C:12]([CH:17]([CH3:21])[C:18](O)=[O:19])[CH:11]=[CH:10]2>C(Cl)(Cl)Cl>[CH3:5][O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[CH:13]=[C:12]([CH:17]([CH3:21])[C:18]([Cl:3])=[O:19])[CH:11]=[CH:10]2

Participants

4

Reactant 2

HCID 13022-(6-Methoxy-2-naphthyl)propionic acidHCID 24386Thionyl Chloride

Product 1

HCID 101988292-(6-methoxynaphthalen-2-yl)propanoyl Chloride

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

7 ml of thionyl chloride were cautiously added to a solution of 2.3 g of 2-(6-methoxy-2-naphtyl)propionic acid in 15 ml of anhydrous chloroform. The reaction mixture was stirred for 40 minutes at room temperature and then the solvent was evaporated at a reduced pressure, obtaining 2.23 g of 2-(6-methoxy-2-naphtyl)propionylchloride.

Workup

  1. customthe solvent was evaporated at a reduced pressure

Sources & evidence

ORD record
ord-942f26f0325747ce85a01583f535b866
Source dataset
uspto-grants-1997_12
Patent number
US05700947

Reaction notes

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