o-(Trifluoromethyl)benzaldehyde → HCID 88365257, compound

HRID 1940976Notes

Reaction equation

HRID 1940976 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:20])=[C:6]([CH:19]=1)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]([F:18])([F:17])[F:16])=O.BrC1C=C(Cl)C=CC=1[O:29][CH2:30][O:31][CH2:32][CH2:33]OC.FC(F)(F)C1C=CC=C[C:39]=1[CH:40]=[O:41]>>[CH2:32]([O:31][C:30]([C:39]1[C:40](=[O:41])[O:20][C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:19][C:6]=2[C:7]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]([F:18])([F:17])[F:16])=[O:29])[CH3:33]

Participants

4

Reactant 3

HCID 123067o-(Trifluoromethyl)benzaldehydeHCID 21463257HCID 21463257, compoundHCID 21463259HCID 21463259, compound

Product 1

HCID 88365257HCID 88365257, compound

Procedure

5-Chloro-2-hydroxy-2'-(trifluoromethyl)benzophenone [prepared from 2-bromo-4-chloro-(2-methyoxyethoxy)methoxybenzene and ortho-(trifluoromethyl)benzaldehyde as the starting materials: melting point, 71°-72° C. (recrystallized from hexane-isopropyl ether)] was reacted by a method similar to Process 1 of Reference Example 25 to yield 6-chloro-2-oxo-4-[2-(trifluoromethyl)phenyl)-2H-1-benzopyran-3-carboxylic acid ethyl ester as an oily substance.

Workup

  1. custompoint, 71°-72° C. (recrystallized from hexane-isopropyl ether)]
  2. customwas reacted by a method similar to Process 1 of Reference Example 25

Sources & evidence

ORD record
ord-71eb56b2e05b430ebc07e6fdbd31f843
Source dataset
uspto-grants-1997_12
Patent number
US05700810

Reaction notes

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