反应详情

Into a reactor, 30 g of 6-bromo-1-hexanol, 18.4 g of triethylamine, and 500 ml of benzene were charged, to which a solution of 16.5 g of acryloyl chloride in 200 ml of benzene was added dropwise, while stirring and cooling with ice, and stirred for 3 hours to give a reaction solution. The reaction solution was washed with a 3N-HCl and then with water, dried over sodium sulfate anhydride, and thereafter the solvent was evaporated and the residue was purified by the silica gel column chromatography (eluent; toluene) to give 25.4 g (Y., 65.1%) of 6-bromohexyl acrylate.

1. additionwas added dropwise
2. temperaturecooling with ice
3. stirringstirred for 3 hours
4. customto give a reaction solution
5. washThe reaction solution was washed with a 3N-HCl
6. dry with materialwith water, dried over sodium sulfate anhydride
7. customthe solvent was evaporated
8. customthe residue was purified by the silica gel column chromatography (eluent; toluene)