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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1940989Generated: October 31, 2026

4-Bromophenol → 4-Bromo-2-fluoro-1-(methoxymethoxy)benzene

https://huagongshe.com/reaction/1940989

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-BromophenolHCID 7808—
Reactant4-Bromo-2-fluorophenolHCID 2724981—
Reactant2,3-Difluorobiphenyl-4'-yl acrylateHCID 21459496—
Product4-Bromo-2-fluoro-1-(methoxymethoxy)benzeneHCID 2203201586.4%

Reaction Steps

The same procedure as in the synthesis (a) of Example 1 was repeated except that 43.9 g of 2-fluoro-4-bromophenol were used instead of 40 g of p-bromophenol to give 46.7 g (Y., 86.4%) of methoxymethy 4-bromo-2-fluorophenyl ether.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05702642
Source datasetuspto-grants-1997_12
ORD IDord-3cb8935d361e4f58a1297585273c031b
Source noteuspto-grants-1997_12