4-Bromophenol → 4-Bromo-2-fluoro-1-methoxymethoxy-benzene

HRID 1940989Notes

Reaction equation

HRID 1940989 reaction equation
[C:1]([O:5][C:6]1C=CC(C2C=CC=C(F)C=2F)=CC=1)(=O)C=C.[F:20][C:21]1[CH:26]=[C:25]([Br:27])[CH:24]=[CH:23][C:22]=1[OH:28].C1C(O)=CC=C(Br)C=1>>[Br:27][C:25]1[CH:24]=[CH:23][C:22]([O:28][CH2:1][O:5][CH3:6])=[C:21]([F:20])[CH:26]=1

Participants

4

Reactant 3

HCID 78084-BromophenolHCID 27249814-Bromo-2-fluorophenolHCID 214594962,3-Difluorobiphenyl-4'-yl acrylate

Product 1

HCID 220320154-Bromo-2-fluoro-1-methoxymethoxy-benzeneYield 86.4%

Procedure

The same procedure as in the synthesis (a) of Example 1 was repeated except that 43.9 g of 2-fluoro-4-bromophenol were used instead of 40 g of p-bromophenol to give 46.7 g (Y., 86.4%) of methoxymethy 4-bromo-2-fluorophenyl ether.

Sources & evidence

ORD record
ord-3cb8935d361e4f58a1297585273c031b
Source dataset
uspto-grants-1997_12
Patent number
US05702642

Reaction notes

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