Water → HCID 21459535, compound

HRID 1940998Notes

Reaction equation

HRID 1940998 reaction equation
[Br:1][C:2]1[C:6]([C:7]#[N:8])=[C:5]([Br:9])[NH:4][C:3]=1[C:10]#[N:11].[C:12](=O)([O-])[O-].[K+].[K+].CI.O>CC(C)=O>[Br:1][C:2]1[C:6]([C:7]#[N:8])=[C:5]([Br:9])[N:4]([CH3:12])[C:3]=1[C:10]#[N:11]

Participants

6

Reactant 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 21459507HCID 21459507, compound

Product 1

HCID 21459535HCID 21459535, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A sample (1.0 g, 0.0036 mol) of 3,5-dibromopyrrole-2,4-dicarbonitrile is readily soluble in 20 mL of acetone. Anhydrous potassium carbonate (0.64 g, 0.0046 mol) is added, and while the slurry is stirred, methyl iodide (0.68 g, 0.0047 mol) is added. The reaction can be followed by Tlc. When the reaction is complete, the mixture is poured into water precipitating a white solid. The product (0.77 g, 74%) has mp 175°-178° C.

Workup

  1. customThe reaction

Sources & evidence

ORD record
ord-93b8a7142b0444c5b57f624f4bd6d05a
Source dataset
uspto-grants-1997_12
Patent number
US05702681

Reaction notes

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