Sodium Hydroxide → HCID 18925574, compound

HRID 1941017Notes

Reaction equation

HRID 1941017 reaction equation
[CH3:1][C:2]12[CH2:29][CH:5]([C:6]3([CH3:28])[C:10]1([CH3:11])[C:9]1[CH:12]=[C:13]([C:16]([C:18]4[CH:27]=[CH:26][C:21]([C:22]([O:24]C)=[O:23])=[CH:20][CH:19]=4)=[O:17])[CH:14]=[CH:15][C:8]=1[O:7]3)[CH2:4][CH2:3]2.[OH-].[Na+]>CO>[CH3:1][C:2]12[CH2:29][CH:5]([C:6]3([CH3:28])[C:10]1([CH3:11])[C:9]1[CH:12]=[C:13]([C:16]([C:18]4[CH:19]=[CH:20][C:21]([C:22]([OH:24])=[O:23])=[CH:26][CH:27]=4)=[O:17])[CH:14]=[CH:15][C:8]=1[O:7]3)[CH2:4][CH2:3]2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 21459573HCID 21459573, compound

Product 1

HCID 18925574HCID 18925574, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.52 g (6.44 mmol) of the ester obtained in Example 8, in solution in 30 ml of methanol, were treated with 2.5 g of sodium hydroxide and heated at reflux for 3 hours. After the same treatment as in Example 7, followed by recrystallization from hexane, 2.35 g (97%) of the expected coompound, melting at 262°-264° C., are isolated.

Workup

  1. temperatureheated
  2. temperatureat reflux for 3 hours
  3. customAfter the same treatment as in Example 7, followed by recrystallization from hexane, 2.35 g (97%) of the expected coompound, melting at 262°-264° C.
  4. customare isolated

Sources & evidence

ORD record
ord-4c3bf28ed02a4cb4b2697217059896c3
Source dataset
uspto-grants-1997_12
Patent number
US05702710

Reaction notes

Loading…