Ammonium Chloride → HCID 21459583, compound

HRID 1941018Notes

Reaction equation

HRID 1941018 reaction equation
[CH3:1][C:2]12[CH2:28][CH:5]([C:6]3([CH3:27])[C:10]1([CH3:11])[C:9]1[CH:12]=[C:13]([C:16]([C:18]4[CH:26]=[CH:25][C:21]([C:22](O)=[O:23])=[CH:20][CH:19]=4)=[O:17])[CH:14]=[CH:15][C:8]=1[O:7]3)[CH2:4][CH2:3]2.[H-].[Al+3].[Li+].[H-].[H-].[H-].[Cl-].[NH4+]>O1CCCC1>[CH3:1][C:2]12[CH2:28][CH:5]([C:6]3([CH3:27])[C:10]1([CH3:11])[C:9]1[CH:12]=[C:13]([CH:16]([OH:17])[C:18]4[CH:19]=[CH:20][C:21]([CH2:22][OH:23])=[CH:25][CH:26]=4)[CH:14]=[CH:15][C:8]=1[O:7]3)[CH2:4][CH2:3]2

Participants

5

Reactant 3

HCID 25517Ammonium ChlorideHCID 18925574HCID 18925574, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 21459583HCID 21459583, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 3.76 g (10 mmol) of the acid obtained in Example 9 was added dropwise to a suspension of 1.14 g of lithium aluminium hydride in 10 ml of tetrahydrofuran and the reaction mixture was maintained under stirring for 3 hours at room temperature. The reaction mixture was neutralized at 0° C. by dropwise addition of a saturated ammonium chloride solution. The precipitate was filtered off, washed with hexane and dried to yield 3.13 g (86%) of the expected compound, melting at 113°-115° C.

Workup

  1. temperaturethe reaction mixture was maintained
  2. filtrationThe precipitate was filtered off
  3. washwashed with hexane
  4. customdried

Sources & evidence

ORD record
ord-50caee4f325e4ebaabda01fb4e3a2d1d
Source dataset
uspto-grants-1997_12
Patent number
US05702710

Reaction notes

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