反应详情

In a three necked flask equipped with a dropping funnel, a thermometer and a reflux condenser, 138 g of p-nitroaniline was dissolved in a mixed solvent consisting of 3000 ml of tetrahydrofuran and 140 ml of pyridine while passing nitrogen gas through the flask. Then, 364 g of eicosanoylchloride placed in the dropping funnel was gradually dropped into the flask over a time span of 20 minutes, while stirring the reaction mixture. After the completion of the dropping, the reaction mixture was further stirred for 2 hours. A solid reaction product was produced. The solid reaction product was collected by filtering, the filtrate was concentrated under a reduced pressure to produce crystals. The crystals were collected and recrystallized from ethyl alcohol. As a result, 355 g of 4'-nitro-n-eicosane anilide was obtained at a yield of 82%.

1. customIn a three necked flask equipped with a dropping funnel
2. additionwas gradually dropped into the flask over a time span of 20 minutes
3. stirringAfter the completion of the dropping, the reaction mixture was further stirred for 2 hours
4. customA solid reaction product
5. customwas produced
6. customThe solid reaction product
7. customwas collected
8. filtrationby filtering
9. concentrationthe filtrate was concentrated under a reduced pressure
10. customto produce crystals
11. customThe crystals were collected
12. customrecrystallized from ethyl alcohol