4-Aminobenzonitrile → HCID 15521688, compound

HRID 1941089Notes

Reaction equation

HRID 1941089 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[N:10]([CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])=[C:11]=[O:12]>C(COC)OC>[C:6]([C:5]1[CH:8]=[CH:9][C:2]([NH:1][C:11](=[O:12])[NH:10][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:3][CH:4]=1)#[N:7]

Participants

4

Reactant 2

HCID 133964-AminobenzonitrileHCID 76283Ethyl isocyanatoacetate

Product 1

HCID 15521688HCID 15521688, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent2×

Procedure

A solution of 2.74 g (23 mmol) of 4-aminobenzonitrile in 10 ml of dimethoxyethane is added dropwise to a cooled solution (0° C.) of 3 g (23 mmol) of ethyl isocyanatoacetate in 10 ml of dimethoxyethane and the mixture is stirred at room temperature. The product is filtered off and washed with dimethoxyethane.

Workup

  1. filtrationThe product is filtered off
  2. washwashed with dimethoxyethane

Sources & evidence

ORD record
ord-20e7acd3db2f472ea206a5a110c4b90d
Source dataset
uspto-grants-1997_12
Patent number
US05703050

Reaction notes

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