Hydrochloric Acid → HCID 86751763, compound

HRID 1941090Notes

Reaction equation

HRID 1941090 reaction equation
[ClH:1].[C:2]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:19])[NH:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:6][CH:5]=1)#[N:3].[CH2:20]([OH:22])[CH3:21]>>[ClH:1].[CH2:20]([O:22][N:3]=[CH:2][C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:19])[NH:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:6][CH:5]=1)[CH3:21]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 15521688HCID 15521688, compound

Product 1

HCID 86751763HCID 86751763, compound

Conditions

Temperature
0 °C

Procedure

Dry HCl gas is introduced with stirring and cooling (0° C.) into a suspension of 2.3 g (9.3 mmol) of ethyl 3-(4-cyanophenyl)ureidoacetate in 50 ml of anhydrous ethanol. After 30 h, the mixture is concentrated in vacuo. The residue is stirred with ether and filtered off.

Workup

  1. concentrationthe mixture is concentrated in vacuo
  2. stirringThe residue is stirred with ether
  3. filtrationfiltered off

Sources & evidence

ORD record
ord-998040d4502549fab9593ed7da4c79b0
Source dataset
uspto-grants-1997_12
Patent number
US05703050

Reaction notes

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