Sodium Hydroxide → HCID 21459791, compound

HRID 1941097Notes

Reaction equation

HRID 1941097 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][NH:12][C:13](=[O:26])[NH:14][C:15]1[CH:16]=[C:17]([CH:23]=[CH:24][CH:25]=1)[C:18]([O:20]CC)=[O:19])=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+]>C(O)C>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][NH:12][C:13](=[O:26])[NH:14][C:15]1[CH:16]=[C:17]([CH:23]=[CH:24][CH:25]=1)[C:18]([OH:20])=[O:19])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 21459767HCID 21459767, compound

Product 1

HCID 21459791HCID 21459791, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.50 g (6.84 mmol) of ethyl 3-(3-(3-tert-butyloxycarbonylaminopropyl)ureido)benzoate are dissolved in 80 ml of ethanol and treated with 3.42 ml of 2N NaOH. After 7 d at room temperature, the mixture is concentrated in vacuo. The residue is treated with water, and the mixture is acidified with citric acid and extracted with ethyl acetate. After drying (MgSO4), solid is filtered off and the solvent is removed in vacuo.

Workup

  1. concentrationthe mixture is concentrated in vacuo
  2. additionThe residue is treated with water
  3. extractionextracted with ethyl acetate
  4. dry with materialAfter drying (MgSO4), solid
  5. filtrationis filtered off
  6. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-254efbe1ea8e46b9a16097f3d8b04eaf
Source dataset
uspto-grants-1997_12
Patent number
US05703050

Reaction notes

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