Sodium Hydroxide → HCID 21459791, compound

Participants

Reaction Steps

2.50 g (6.84 mmol) of ethyl 3-(3-(3-tert-butyloxycarbonylaminopropyl)ureido)benzoate are dissolved in 80 ml of ethanol and treated with 3.42 ml of 2N NaOH. After 7 d at room temperature, the mixture is concentrated in vacuo. The residue is treated with water, and the mixture is acidified with citric acid and extracted with ethyl acetate. After drying (MgSO4), solid is filtered off and the solvent is removed in vacuo.

Provenance & Evidence