Hydrochloric Acid → HCID 54208840, compound

HRID 1941101Notes

Reaction equation

HRID 1941101 reaction equation
[C:1]([C:3]1[CH:27]=[CH:26][C:6]([CH2:7][N:8]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:9](=[O:17])[NH:10][CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:5][CH:4]=1)#[N:2].Cl.[CH2:29]([OH:31])[CH3:30]>>[CH2:29]([O:31][N:2]=[CH:1][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][N:8]([O:18][CH2:19][C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:9](=[O:17])[NH:10][CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:26][CH:27]=1)[CH3:30]

Participants

4

Reactant 3

HCID 313Hydrochloric Acid2×HCID 702EthanolHCID 54468236HCID 54468236, compound

Product 1

HCID 54208840HCID 54208840, compound

Conditions

Temperature
-30 °C

Procedure

2.99 g (8.14 mmol) of ethyl (3-(4-cyanobenzyl)-3-benzyloxyureido)acetate are dissolved in 250 ml of ethanol and cooled to -30° C. Dry HCl gas is introduced into the solution. After 24 h, excess HCl gas is driven out by nitrogen and the solvent is removed in vacuo. The residue crystallizes from ethyl acetate/ether.

Workup

  1. customthe solvent is removed in vacuo
  2. customThe residue crystallizes from ethyl acetate/ether

Sources & evidence

ORD record
ord-a23193ec069642c5857af6ee46296d6c
Source dataset
uspto-grants-1997_12
Patent number
US05703050

Reaction notes

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