Water → HCID 86751772, compound

HRID 1941103Notes

Reaction equation

HRID 1941103 reaction equation
[C:1]([O:5][C:6]([NH:8][N:9]=[CH:10][C:11]1[CH:35]=[CH:34][C:14]([CH2:15][N:16]([O:26][CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:17](=[O:25])[NH:18][CH2:19][C:20]([O:22]CC)=[O:21])=[CH:13][CH:12]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+:37].O>C(O)C>[C:1]([O:5][C:6]([NH:8][N:9]=[CH:10][C:11]1[CH:35]=[CH:34][C:14]([CH2:15][N:16]([O:26][CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:17](=[O:25])[NH:18][CH2:19][C:20]([O-:22])=[O:21])=[CH:13][CH:12]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3].[Na+:37]

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 86751771HCID 86751771, compound

Product 1

HCID 86751772HCID 86751772, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.78 g (5.74 mmol) of ethyl (3-(4-(tert-butyloxycarbonylaminoiminomethyl)benzyl)-3-benzyloxyureido)acetate in 50 ml of ethanol are treated with 0.23 g (5.74 mmol) of NaOH and 1.2 ml of water and the mixture is stirred at room temperature for 18 h. The solvent is removed in vacuo and the residue is freeze-dried.

Workup

  1. customThe solvent is removed in vacuo
  2. customthe residue is freeze-dried

Sources & evidence

ORD record
ord-cebfd883ae3f457792f9835f1f4d554b
Source dataset
uspto-grants-1997_12
Patent number
US05703050

Reaction notes

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