反应详情

1.4 g (3 mmol) of methyl 3-benzyloxy-3-phenyl-2-(4,6-dimethoxypyrimidin-2-yloxy)butyrate (Example 3) are dissolved in 20 ml of methanol and 20 ml of tetrahydrofuran, and 3.7 g of 10% strength NaOH solution are added. Stirring is carried out for 6 hours at 60° C. and for 12 hours at room temperature, the solvent is distilled off under reduced pressure and the residue is taken up in 100 ml of water. Extraction is now carried out with ethyl acetate to remove unconverted ester. The aqueous phase is then brought to pH 1-2 with dilute hydrochloric acid and is extracted with ethyl acetate. After drying has been carried out over magnesium sulfate and the solvent has been distilled off, a little acetone is added to the residue and the precipitate formed is filtered off with suction. After drying, 1.2 g of a white powder remain.

1. distillationthe solvent is distilled off under reduced pressure
2. extractionExtraction
3. customto remove unconverted ester
4. extractionis extracted with ethyl acetate
5. customAfter drying
6. distillationthe solvent has been distilled off
7. additiona little acetone is added to the residue
8. customthe precipitate formed
9. filtrationis filtered off with suction
10. customAfter drying