Acetone → 3-{2-[3-(4-Fluorobenzoylmethyl)pyrrolidin-1-yl]ethyl}-5-methoxyindole hydrochloride

HRID 1941116Notes

Reaction equation

HRID 1941116 reaction equation
[ClH:1].CC(C)=O.[F:6][C:7]1[CH:33]=[CH:32][C:10]([C:11]([CH2:13][CH:14]2[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C:21]3[C:29]4[C:24](=[CH:25][CH:26]=[C:27]([O:30][CH3:31])[CH:28]=4)[NH:23][CH:22]=3)[CH2:15]2)=[O:12])=[CH:9][CH:8]=1>C(O)C>[ClH:1].[F:6][C:7]1[CH:33]=[CH:32][C:10]([C:11]([CH2:13][CH:14]2[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C:21]3[C:29]4[C:24](=[CH:25][CH:26]=[C:27]([O:30][CH3:31])[CH:28]=4)[NH:23][CH:22]=3)[CH2:15]2)=[O:12])=[CH:9][CH:8]=1

Participants

5

Reactant 3

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 110253113-{2-[3-(4-Fluorobenzoylmethyl)pyrrolidin-1-yl]ethyl}-5-methoxyindole

Product 1

HCID 214599133-{2-[3-(4-Fluorobenzoylmethyl)pyrrolidin-1-yl]ethyl}-5-methoxyindole hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

One equivalent of hydrogen chloride in solution in ethanol is added to an acetone solution of the product obtained in Stage 3. Complete evaporation of the solvents results in the hydrochloride of the compound mentioned.

Workup

  1. customComplete evaporation of the solvents

Sources & evidence

ORD record
ord-8b9eda9e6b0a4042adda4389ad5644b0
Source dataset
uspto-grants-1997_12
Patent number
US05703070

Reaction notes

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