反应详情

温度

-78 °C

7-formyl-4-isopropyl-2-hydroxy-2,4,6-cycloheptatrien-1-one (2.00 g, 10 mmol) was dissolved in tetrahydrofuran (20 ml) and cooled to -78° C. in a dry ice/acetone bath. A solution of methyllithium the ether (1.4M, 15 ml) was added dropwise to the solution, then dry ice/acetone bath was removed and stirring was continued until the insolubles were dissolved. An aqueous saturated ammonium chloride was added to the reaction mixture and extracted with methylene chloride. The methylene chloride layer was washed with water, dried over anhydrous sodium sulfate and solvent was distilled off to give 2.18 g of 7-(α-hydroxyethyl)-4-isopropyl-2-hydroxy-2,4,6-cycloheptatrien-1-one as a reddish brown oil (yield: quantitative).

1. customdry ice/acetone bath was removed
2. dissolutionwere dissolved
3. additionAn aqueous saturated ammonium chloride was added to the reaction mixture
4. extractionextracted with methylene chloride
5. washThe methylene chloride layer was washed with water
6. dry with materialdried over anhydrous sodium sulfate and solvent
7. distillationwas distilled off