Urea → HCID 21460389, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 2-(2-benzyloxyethylamino)-2-methylpropionate (29 g) and urea (8.5 g) was heated at 180° C. for 1 h. After cooling to room temperature water (250 ml) was added and the resulting mixture was extracted with diethyl ether (500 ml). The organic phase was washed with brine (400 ml) and dried (Na2SO4). Evaporation of the solvents in vacuo afforded 9a as an oil: 28 g.

Provenance & Evidence