Urea → HCID 21460389, compound

HRID 1941217Notes

Reaction equation

HRID 1941217 reaction equation
[CH2:1]([O:8][CH2:9][CH2:10][NH:11][C:12]([CH3:19])([CH3:18])[C:13]([O:15]CC)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:20][C:21](N)=[O:22]>O>[CH2:1]([O:8][CH2:9][CH2:10][N:11]1[C:12]([CH3:18])([CH3:19])[C:13](=[O:15])[NH:20][C:21]1=[O:22])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 1176UreaHCID 21460406HCID 21460406, compound

Product 1

HCID 21460389HCID 21460389, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
180 °C

Procedure

A mixture of ethyl 2-(2-benzyloxyethylamino)-2-methylpropionate (29 g) and urea (8.5 g) was heated at 180° C. for 1 h. After cooling to room temperature water (250 ml) was added and the resulting mixture was extracted with diethyl ether (500 ml). The organic phase was washed with brine (400 ml) and dried (Na2SO4). Evaporation of the solvents in vacuo afforded 9a as an oil: 28 g.

Workup

  1. additionwas added
  2. extractionthe resulting mixture was extracted with diethyl ether (500 ml)
  3. washThe organic phase was washed with brine (400 ml)
  4. dry with materialdried (Na2SO4)
  5. customEvaporation of the solvents in vacuo

Sources & evidence

ORD record
ord-3265a55fb45b4d4482b10d08a2a0984a
Source dataset
uspto-grants-1997_12
Patent number
US05703087

Reaction notes

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