反应详情

温度

-70 °C

1-(4-cyanobenzyl)-imidazole (1 g, 0.0054 mol) is dissolved into dry tetrahydrofuran (30 ml) and cooled to -70° C. n-BuLi in hexane (0.0054 mol) is added dropwise into the reaction mixture. After stirring for additional 30 min at -70° C. 3-(4-fluorophenyl)propyl bromide (1.5 g, 0,0069 mol) in THF (10 ml) is added to the mixture and stirring is continued for 2 hours. Then the mixture is allowed to warm to room temperature. Saturated aqueous ammonium chloride solution is added to the mixture, shaked and then the layers are separated. THF-phase is dried and evaporated to dryness. The residue is crystallized from isopropanol as hydrogen chloride salt. The filtrate is purified by flash chromatography.

1. additionis added dropwise into the reaction mixture
2. stirringstirring
3. waitis continued for 2 hours
4. temperatureto warm to room temperature
5. customshaked and then the layers are separated
6. dry with materialTHF-phase is dried
7. customevaporated to dryness
8. customThe residue is crystallized from isopropanol as hydrogen chloride salt
9. customThe filtrate is purified by flash chromatography