Hydrochloric Acid → HCID 21843582, compound

HRID 1941292Notes

Reaction equation

HRID 1941292 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:19])[CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)=[CH:5][CH:4]=1)#[N:2].[BH4-].[Na+].Cl>CO>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([CH:9]([OH:19])[CH2:10][CH2:11][C:12]2[CH:13]=[CH:14][C:15]([F:18])=[CH:16][CH:17]=2)=[CH:7][CH:8]=1)#[N:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 218435754-[3-(4-Fluorophenyl)propanoyl]benzonitrile

Product 1

HCID 21843582HCID 21843582, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
30 °C

Procedure

1-(4-cyanophenyl)-3-(4-fluorophenyl)-1-propanone (6.35 g, 25 mmol) is dissolved in methanol (50 ml). Sodium borohydride (0.48 g, 12.6 mmol) is added and the mixture is stirred in 30° C. for 1 h. The mixture is rendered acidic with 2M hydrochloric acid and the solvent is evaporated. The residue is dissolved into ethyl acetate. The solution is washed with dilute sodium hydroxide and water, dried and the solvent is evaporated. The product is used for the next step without further purification.

Workup

  1. customthe solvent is evaporated
  2. dissolutionThe residue is dissolved into ethyl acetate
  3. washThe solution is washed with dilute sodium hydroxide and water
  4. customdried
  5. customthe solvent is evaporated
  6. customThe product is used for the next step without further purification

Sources & evidence

ORD record
ord-405b2401fbdd4983afdea12efb5f9dc0
Source dataset
uspto-grants-1997_12
Patent number
US05703109

Reaction notes

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