Potassium bisulfate → HCID 70276086, compound

HRID 1941298Notes

Reaction equation

HRID 1941298 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]([N:20]2[CH:24]=[N:23][CH:22]=[N:21]2)[CH2:10][CH:11]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)O)=[CH:5][CH:4]=1)#[N:2].C(C1C=CC(C(N2C=NC=N2)C=CC2C=CC(F)=CC=2)=CC=1)#N.S([O-])(O)(=O)=O.[K+]>CO>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]([N:20]2[CH:24]=[N:23][CH:22]=[N:21]2)[CH:10]=[CH:11][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)=[CH:5][CH:4]=1)#[N:2]

Participants

4

Reactant 2

HCID 516920Potassium bisulfateHCID 86751777HCID 86751777, compound

Product 1

HCID 70276086HCID 70276086, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-[1-(4-cyanophenyl)-3-(4-fluorophenyl)-2-propenyl]-1,2,4-triazole 1-[1-(4-cyanophenyl)-3-(4-fluorophenyl)-3-hydroxypropyl]-1,2,4-triazole (100 mg) is heated with potassium hydrogen sulfate (400 mg) on oil bath at 140 ° C. for 2 hours. Methanol is added and the inorganic material is filtered off. Methanol is evaporated to give the product as a mixture of cis and trans isomers.

Workup

  1. filtrationthe inorganic material is filtered off
  2. customMethanol is evaporated
  3. customto give the product
  4. additionas a mixture of cis and trans isomers

Sources & evidence

ORD record
ord-d840c8d5d24149548b47226bcbe1c56e
Source dataset
uspto-grants-1997_12
Patent number
US05703109

Reaction notes

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