HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl Peroxide → 5-(4-(Bromomethyl)phenyl)isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl Peroxide | HCID 7187 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 5-(P-Tolyl)isoxazole | HCID 270015 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 5-(4-(Bromomethyl)phenyl)isoxazole | HCID 22997545 | — |
Reaction Steps
To a solution of 5-(4-methylphenyl)-isoxazole (17 g) and N-bromosuccinimide (19 g) in tetrachloromethane (500 ml) under nitrogen, bisbenzoyl peroxide (0.43 g) is added, and the mixture heated on reflux over night. The solvent is evaporated, and the residue purified by flash chromatography (silica gel, hexane/ethyl acetate 4:1) to give pure 5-(4- bromomethylphenyl)-isoxazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05703106 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-fd4ba224a2fe428486e85d57b6cdca3a |
| Source note | uspto-grants-1997_12 |