Benzoyl Peroxide → 5-(4-(Bromomethyl)phenyl)isoxazole

HRID 1941330ノート

反応式

HRID 1941330 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[Br:13]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>ClC(Cl)(Cl)Cl>[Br:13][CH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 2700155-(P-Tolyl)isoxazole

生成物 1

HCID 229975455-(4-(Bromomethyl)phenyl)isoxazole

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

To a solution of 5-(4-methylphenyl)-isoxazole (17 g) and N-bromosuccinimide (19 g) in tetrachloromethane (500 ml) under nitrogen, bisbenzoyl peroxide (0.43 g) is added, and the mixture heated on reflux over night. The solvent is evaporated, and the residue purified by flash chromatography (silica gel, hexane/ethyl acetate 4:1) to give pure 5-(4- bromomethylphenyl)-isoxazole.

後処理

  1. temperaturethe mixture heated
  2. temperatureon reflux over night
  3. customThe solvent is evaporated
  4. customthe residue purified by flash chromatography (silica gel, hexane/ethyl acetate 4:1)

出典と根拠

ORDレコード
ord-fd4ba224a2fe428486e85d57b6cdca3a
出典データセット
uspto-grants-1997_12
特許番号
US05703106

反応ノート

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