HCID 22106551, compound → HCID 22106524, compound

HRID 1941499Notes

Reaction equation

HRID 1941499 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[C:19]([CH3:20])=[N:18][N:17]=[N:16]2)=[CH:11][C:10]=1[F:21])C1C=CC=CC=1>C(O)C.[Pd]>[F:21][C:10]1[CH:11]=[C:12]([N:15]2[C:19]([CH3:20])=[N:18][N:17]=[N:16]2)[CH:13]=[CH:14][C:9]=1[OH:8]

Participants

4

Reactant 1

HCID 22106551HCID 22106551, compound

Product 1

HCID 22106524HCID 22106524, compoundYield 114.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A suspension of 1-(4-benzyloxy-3-fluoro-phenyl)-5-methyl-1H-tetrazole (4.6 g) in ethanol (300 ml) was hydrogenated at room temperature and pressure over a pre-reduced suspension of palladium-on-carbon (10% paste, 1.4 g) until uptake ceased. The catalyst was filtered off and the filtrate evaporated to give the title compound as a cream solid (3.6 g). T.l.c. (Dichloromethane/methanol (995:5)), Rf 0.45.

Workup

  1. customwas hydrogenated at room temperature
  2. filtrationThe catalyst was filtered off
  3. customthe filtrate evaporated

Sources & evidence

ORD record
ord-9947171d0615468ba16bc0ede2f4248b
Source dataset
uspto-grants-1997_12
Patent number
US05703240

Reaction notes

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