HCID 22106522, compound → HCID 22106583, compound

HRID 1941502Notes

Reaction equation

HRID 1941502 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[C:19]([CH:20]3[CH2:22][CH2:21]3)=[N:18][N:17]=[N:16]2)=[CH:11][CH:10]=1)C1C=CC=CC=1>C(O)C.[Pd]>[CH:20]1([C:19]2[N:15]([C:12]3[CH:11]=[CH:10][C:9]([OH:8])=[CH:14][CH:13]=3)[N:16]=[N:17][N:18]=2)[CH2:22][CH2:21]1

Participants

4

Reactant 1

HCID 22106522HCID 22106522, compound

Product 1

HCID 22106583HCID 22106583, compoundYield 98.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent2×

Procedure

A solution of 1-(4-benzyloxy-phenyl)-5-cyclopropyl-1H-tetrazole (2.3 g) in ethanol (75 ml) was added to a suspension of 10% palladium on charcoal catalyst (400 mg) in ethanol (10 ml) and the mixture was stirred under a hydrogen atmosphere for 1 h. The catalyst was removed by filtration and the solution concentrated in vacuo to afford the title compound (1.57 g) as a pale yellow solid, m.p. 184°.

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe solution concentrated in vacuo

Sources & evidence

ORD record
ord-c7b854f9b4874d96acd430360a511ee6
Source dataset
uspto-grants-1997_12
Patent number
US05703240

Reaction notes

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