反应详情

Active manganese dioxide (77 mg) was added to a stirred solution of 2-methoxy-5-(tetrazol-1-yl)phenylmethanol (40 mg) in tetrahydrofuran (1 ml). After 30 min the mixture was heated in an oil-bath at 70°. After a further 30 min, active manganese dioxide (67 mg) was added. After a further 1 h the mixture was allowed to cool and then filtered. The filtrate was evaporated to give the title compound as a yellow solid (33 mg); nmr, δ (d6 -DMSO), 4.4 (s,3H), 7.53 (d, 1H, J=ca 10 Hz), 8.12-8.23 (m, 2H), 10.12 (s, 1H), 10.40 (s, 1H).

1. temperatureAfter 30 min the mixture was heated in an oil-bath at 70°
2. waitAfter a further 1 h the mixture was allowed
3. temperatureto cool
4. filtrationfiltered
5. customThe filtrate was evaporated