HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1-Dimethylethyl N-(aminosulfonyl)carbamate → 1,1-Dimethylethyl N-(aminosulfonyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1-Dimethylethyl N-(aminosulfonyl)carbamate | HCID 10726542 | — |
| Reactant | (2R,4R)-Tert-butyl 4-(acetylthio)-2-(hydroxymethyl)pyrrolidine-1-carboxylate | HCID 53748200 | — |
| Product | 1,1-Dimethylethyl N-(aminosulfonyl)carbamate | HCID 10726542 | — |
| Product | (2R,4R)-4-acetylthio-1-t-butoxycarbonyl-2-(N-t-butoxycarbonyl-N-sulfamoylamino)methylpyrrolidine | HCID 54004215 | — |
Reaction Steps
N-t-butoxycarbonylsulfamide is prepared in the same manner as in the paragraph (a) of Step A-6 in preparative Example 7-A. (2R,4R)-4-acetylthio-1-t-butoxycarbonylpyrrolidine-2-methanol (i.e., a substrate) is allowed to react with the obtained N-t-butoxycarbonylsulfamide in the similar manner as in paragraph (b) of Step A-6 in Preparative Example 7-A under a condition for Step B-6 shown in Table 2 to give (2R,4R)-4-acetylthio-1-t-butoxycarbonyl-2-(N-t-butoxycarbonyl-N-sulfamoylamino)methylpyrrolidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05703243 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-cc33a756bc1f4abb99afaa3f48c2c01b |
| Source note | uspto-grants-1997_12 |