Triphenylphosphine → HCID 86751799, compound

HRID 1941635Notes

Reaction equation

HRID 1941635 reaction equation
[C:1]1([C:7]2[CH:8]=[C:9]([CH:16]=[CH:17][CH:18]=2)[CH:10]=[N:11][O:12][CH2:13][CH2:14][OH:15])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O[C:20]1[CH:52]=[CH:51][C:23]([CH2:24][CH:25]2[S:29][C:28](=[O:30])[N:27]([C:31]([C:44]3[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=3)([C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=3)[C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[C:26]2=[O:50])=[CH:22][CH:21]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N(C(OCC)=O)=NC(OCC)=O>>[C:1]1([C:7]2[CH:8]=[C:9]([CH:16]=[CH:17][CH:18]=2)[CH:10]=[N:11][O:12][CH2:13][CH2:14][O:15][C:20]2[CH:52]=[CH:51][C:23]([CH2:24][CH:25]3[S:29][C:28](=[O:30])[N:27]([C:31]([C:44]4[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=4)([C:38]4[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=4)[C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)[C:26]3=[O:50])=[CH:22][CH:21]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 4

HCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 28181265-(4-Hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dioneHCID 53783169HCID 53783169, compound

Product 1

HCID 86751799HCID 86751799, compoundYield 76.2%

Procedure

Following a procedure similar to that described in Example 1(a), but using 483 mg of 2-(3-phenylbenzylideneaminooxy)ethanol (prepared as described in Preparation 8), 716 mg of 5-(4-hydroxybenzyl)-3-tritylthiazolidine-2,4-dione, 525 mg of triphenylphosphine and 348 mg of diethyl azodicarboxylate, 807 mg of the title compound were obtained as a foam-like solid.

Sources & evidence

ORD record
ord-0d70bc72cf1c4b3d92a7845cf9ef5b7d
Source dataset
uspto-grants-1997_12
Patent number
US05703096

Reaction notes

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