HCID 10471772, compound → HCID 12082818, compound

HRID 1941699Notes

Reaction equation

HRID 1941699 reaction equation
[OH:1][CH2:2][C:3]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]([C:14]2[CH:19]=[CH:18][C:17]([S:20]([NH2:23])(=[O:22])=[O:21])=[CH:16][CH:15]=2)[N:4]=1>C(OCC)(=O)C.O=[Mn]=O>[CH:2]([C:3]1[CH:7]=[C:6]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:5]([C:14]2[CH:19]=[CH:18][C:17]([S:20]([NH2:23])(=[O:22])=[O:21])=[CH:16][CH:15]=2)[N:4]=1)=[O:1]

Participants

4

Reactant 1

HCID 10471772HCID 10471772, compound

Product 1

HCID 12082818HCID 12082818, compound

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of the alcohol prepared in Example 131, Step 3 (1.1 g, 3.3 mmol) in ethyl acetate (20 mL) was added MnO2 (5 g, 60 mmol) and the mixture stirred at room temperature overnight. The mixture was filtered through Celite and the solution was concentrated to provide the crude aldehyde.

Workup

  1. filtrationThe mixture was filtered through Celite
  2. concentrationthe solution was concentrated

Sources & evidence

ORD record
ord-90e1733e1b94481ebc7bb8f99b8044b9
Source dataset
uspto-grants-2013_03
Patent number
USRE044048E1

Reaction notes

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