2-Pyridinecarboxylicacid,5-(2,2,3,3-tetrafluoropropoxy)- → HCID 53240812, compound

HRID 1941827Notes

Reaction equation

HRID 1941827 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([F:18])=[C:6]([C@:8]2([CH3:17])[C:13]([F:15])([F:14])[CH2:12][O:11][C:10]([NH2:16])=[N:9]2)[CH:7]=1.[F:19][C:20]([F:35])([CH:32]([F:34])[F:33])[CH2:21][O:22][C:23]1[CH:24]=[CH:25][C:26]([C:29](O)=[O:30])=[N:27][CH:28]=1>>[NH2:16][C:10]1[O:11][CH2:12][C:13]([F:14])([F:15])[C@:8]([C:6]2[CH:7]=[C:2]([NH:1][C:29]([C:26]3[CH:25]=[CH:24][C:23]([O:22][CH2:21][C:20]([F:35])([F:19])[CH:32]([F:34])[F:33])=[CH:28][N:27]=3)=[O:30])[CH:3]=[CH:4][C:5]=2[F:18])([CH3:17])[N:9]=1

Participants

3

Reactant 2

HCID 574758552-Pyridinecarboxylicacid,5-(2,2,3,3-tetrafluoropropoxy)-HCID 58304207(R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

Product 1

HCID 53240812HCID 53240812, compound

Procedure

The condensation of (R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate XI-1) and 5-(2,2,3,3-tetrafluoro-propoxy)-pyridine-2-carboxylic acid [example 30a), b)] following procedure I yielded the title compound as a white solid. MS (ISP): m/z=495.2 [M+H]+.

Sources & evidence

ORD record
ord-a9b138a5177e4c21a6542676f3983039
Source dataset
uspto-grants-2013_03
Patent number
US08389513B2

Reaction notes

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