HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Pyridinecarboxylicacid,5-(2,2,3,3-tetrafluoropropoxy)- → HCID 53240812, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Pyridinecarboxylicacid,5-(2,2,3,3-tetrafluoropropoxy)- | HCID 57475855 | — |
| Reactant | (R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine | HCID 58304207 | — |
| Product | HCID 53240812 | HCID 53240812 | — |
Reaction Steps
The condensation of (R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate XI-1) and 5-(2,2,3,3-tetrafluoro-propoxy)-pyridine-2-carboxylic acid [example 30a), b)] following procedure I yielded the title compound as a white solid. MS (ISP): m/z=495.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08389513B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-a9b138a5177e4c21a6542676f3983039 |
| Source note | uspto-grants-2013_03 |