1-(Difluoromethyl)-1H-pyrazole-3-carboxylic acid → HCID 53241206, compound

HRID 1941852Notes

Reaction equation

HRID 1941852 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([F:18])=[C:6]([C@:8]2([CH3:17])[C:13]([F:15])([F:14])[CH2:12][O:11][C:10]([NH2:16])=[N:9]2)[CH:7]=1.[F:19][CH:20]([F:29])[N:21]1[CH:25]=[CH:24][C:23]([C:26](O)=[O:27])=[N:22]1>>[NH2:16][C:10]1[O:11][CH2:12][C:13]([F:14])([F:15])[C@:8]([C:6]2[CH:7]=[C:2]([NH:1][C:26]([C:23]3[CH:24]=[CH:25][N:21]([CH:20]([F:29])[F:19])[N:22]=3)=[O:27])[CH:3]=[CH:4][C:5]=2[F:18])([CH3:17])[N:9]=1

Participants

3

Reactant 2

HCID 31541781-(Difluoromethyl)-1H-pyrazole-3-carboxylic acidHCID 58304207(R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

Product 1

HCID 53241206HCID 53241206, compound

Procedure

The condensation of (R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate XI-1) and 1-difluoromethyl-1H-pyrazole-3-carboxylic acid following procedure I yielded the title compound as a white solid. MS (ISP): m/z=404.3 [M+H]+.

Sources & evidence

ORD record
ord-f373ed544af74248b6dfed4c8c23cfa4
Source dataset
uspto-grants-2013_03
Patent number
US08389513B2

Reaction notes

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