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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1941852Generated: October 30, 2026

1-(Difluoromethyl)-1H-pyrazole-3-carboxylic acid → HCID 53241206, compound

https://huagongshe.com/reaction/1941852

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Difluoromethyl)-1H-pyrazole-3-carboxylic acidHCID 3154178—
Reactant(R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamineHCID 58304207—
ProductHCID 53241206HCID 53241206—

Reaction Steps

The condensation of (R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate XI-1) and 1-difluoromethyl-1H-pyrazole-3-carboxylic acid following procedure I yielded the title compound as a white solid. MS (ISP): m/z=404.3 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08389513B2
Source datasetuspto-grants-2013_03
ORD IDord-f373ed544af74248b6dfed4c8c23cfa4
Source noteuspto-grants-2013_03