(R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine → HCID 178421646, compound

HRID 1941855Notes

Reaction equation

HRID 1941855 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([F:18])=[C:6]([C@:8]2([CH3:17])[C:13]([F:15])([F:14])[CH2:12][O:11][C:10]([NH2:16])=[N:9]2)[CH:7]=1.[Cl:19][C:20]1[C:24]([CH:25]2[CH2:27][CH2:26]2)=[N:23][NH:22][C:21]=1[C:28](O)=[O:29]>>[NH2:16][C:10]1[O:11][CH2:12][C:13]([F:14])([F:15])[C@:8]([C:6]2[CH:7]=[C:2]([NH:1][C:28]([C:21]3[NH:22][N:23]=[C:24]([CH:25]4[CH2:26][CH2:27]4)[C:20]=3[Cl:19])=[O:29])[CH:3]=[CH:4][C:5]=2[F:18])([CH3:17])[N:9]=1

Participants

3

Reactant 2

HCID 58304207(R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamineHCID 1785249274-chloro-3-cyclopropyl-1H-pyrazole-5-carboxylic acid

Product 1

HCID 178421646HCID 178421646, compound

Procedure

The condensation of (R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate XI-1) and 4-chloro-5-cyclopropyl-2H-pyrazole-3-carboxylic acid following procedure I yielded the title compound as a white foam. MS (ISP): m/z=428.3 [M+H]+.

Sources & evidence

ORD record
ord-3fe46111782448d6a5432a780c9e2c1a
Source dataset
uspto-grants-2013_03
Patent number
US08389513B2

Reaction notes

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