HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine → HCID 178421646, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine | HCID 58304207 | — |
| Reactant | 4-chloro-3-cyclopropyl-1H-pyrazole-5-carboxylic acid | HCID 178524927 | — |
| Product | HCID 178421646 | HCID 178421646 | — |
Reaction Steps
The condensation of (R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate XI-1) and 4-chloro-5-cyclopropyl-2H-pyrazole-3-carboxylic acid following procedure I yielded the title compound as a white foam. MS (ISP): m/z=428.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08389513B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-3fe46111782448d6a5432a780c9e2c1a |
| Source note | uspto-grants-2013_03 |