HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-1-ethyl-1H-pyrazole-3-carboxylic acid → 4-Chloro-1-ethyl-1H-pyrazole-3-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-1-ethyl-1H-pyrazole-3-carboxylic acid | HCID 589820 | — |
| Reactant | (R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine | HCID 58304207 | — |
| Product | 4-Chloro-1-ethyl-1H-pyrazole-3-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide | HCID 53241398 | — |
Reaction Steps
The condensation of (R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate XI-1) and 4-chloro-1-ethyl-1H-pyrazole-3-carboxylic acid (CAS512810-20-7) following procedure I yielded the title compound as a white solid. MS (ISP): m/z=416.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08389513B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-322b81339a2049c9b0eec05c254502f6 |
| Source note | uspto-grants-2013_03 |