反应详情

40% aqueous methylamine (10 mL, 0.1 mol) was added to a vigorously stirred solution of (3-nitrophenyl)methanesulfonyl chloride (2.36 g, 10 mmol) in benzene (30 mL) and allowed to stir for 2 h at room temperature. The benzene layer was separated, and the aqueous layer extracted with CH2Cl2 (2×25 mL). The combined organic layers were washed with saturated aqueous NaHCO3 (30 mL), water (30 mL), filtered over anhydrous Na2SO4, filtered and the solvent removed under reduced pressure to give 2.07 g (90%) of (3-nitrophenyl)-N-methylmethanesulfonamide as crystals.

1. customThe benzene layer was separated
2. extractionthe aqueous layer extracted with CH2Cl2 (2×25 mL)
3. washThe combined organic layers were washed with saturated aqueous NaHCO3 (30 mL), water (30 mL)
4. filtrationfiltered over anhydrous Na2SO4
5. filtrationfiltered
6. customthe solvent removed under reduced pressure