Benzoyl isothiocyanate → HCID 57813664, compound

HRID 1941936Notes

Reaction equation

HRID 1941936 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([NH2:13])[CH:5]=[C:6]([N:8]2[CH:12]=[CH:11][CH:10]=[N:9]2)[CH:7]=1.[C:14]([N:22]=[C:23]=[S:24])(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>CC(C)=O>[C:14]([NH:22][C:23]([NH:13][C:4]1[CH:5]=[C:6]([N:8]2[CH:12]=[CH:11][CH:10]=[N:9]2)[CH:7]=[C:2]([Br:1])[CH:3]=1)=[S:24])(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 68284Benzoyl isothiocyanateHCID 57813693HCID 57813693, compound

Product 1

HCID 57813664HCID 57813664, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To the solution of 3-bromo-5-pyrazol-1-yl-phenylamine (0.18 g, 0.76 mmol) in anhydrous acetone (5.0 mL) was added benzoylisothiocyanate (0.14 g, 0.83 mmol) and the reaction mixture was stirred at room temperature for 30 min. Acetone was distilled off and the crude residue was washed with hexane to obtain desired compound (0.27 g, 89%).

Workup

  1. distillationAcetone was distilled off
  2. washthe crude residue was washed with hexane

Sources & evidence

ORD record
ord-5d3d2d5a22094b9480c95c1d25677d51
Source dataset
uspto-grants-2013_03
Patent number
US08389516B2

Reaction notes

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