反应详情

温度

70 °C

A solution of NaOH (0.13 g, 3.35 mmol) dissolved in 1.0 mL of H2O was added to a solution of 1-Benzoyl-3-(3-bromo-5-pyrazol-1-yl-phenyl)-thiourea 3 (0.27 g, 0.67 mmol) in 5.0 mL of THF. The resulting reaction mixture was stirred at 70° C. for 12 hours. THF was distilled off and extracted with ethyl acetate (×3). The combined organic layer was dried over Na2SO4, filtered and distilled off to get the crude residue that was washed with 2% Ethyl acetate-hexane to obtain the desired compound (0.17 g, 85%).

1. customThe resulting reaction mixture
2. distillationTHF was distilled off
3. extractionextracted with ethyl acetate (×3)
4. dry with materialThe combined organic layer was dried over Na2SO4
5. filtrationfiltered
6. distillationdistilled off
7. customto get the crude residue that
8. washwas washed with 2% Ethyl acetate-hexane