反应详情

200 mg (1.0 mmol) of the compound from Example 42A and 118 mg (1.0 mmol) of the compound from Example 1A are dissolved in 2 ml ethanol and 44 mg (0.2 mmol) camphor-10-sulfonic acid are added. The mixture is heated under reflux for 16 h and then concentrated and the residue is purified by means of preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient with addition of 0.1% formic acid in the water).

1. temperatureThe mixture is heated
2. temperatureunder reflux for 16 h
3. concentrationconcentrated
4. customthe residue is purified by means of preparative HPLC (RP18 column
5. additionmobile phase: acetonitrile/water gradient with addition of 0.1% formic acid in the water)