Hydrochloric Acid → HCID 67453577, compound

HRID 1942033Notes

Reaction equation

HRID 1942033 reaction equation
[ClH:1].FC(F)(F)C(O)=O.[N:9]1([C:14]2[C:15](=[O:31])[N:16]([C:19]3[CH:24]=[C:23]([N:25]4[CH2:30][CH2:29][O:28][CH2:27][CH2:26]4)[N:22]=[CH:21][N:20]=3)[NH:17][CH:18]=2)[CH:13]=[CH:12][N:11]=[CH:10]1>O1CCOCC1>[ClH:1].[N:9]1([C:14]2[C:15](=[O:31])[N:16]([C:19]3[CH:24]=[C:23]([N:25]4[CH2:26][CH2:27][O:28][CH2:29][CH2:30]4)[N:22]=[CH:21][N:20]=3)[NH:17][CH:18]=2)[CH:13]=[CH:12][N:11]=[CH:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67455675HCID 67455675, compound

Product 1

HCID 67453577HCID 67453577, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

0.5 ml of a 4 N solution of hydrogen chloride in dioxane are added to 60 mg (0.1 mmol) of the compound from Example 73 and the mixture is stirred at RT for 1 h. The solid is filtered off, washed twice with 0.5 ml dioxane each time and subsequently dried in vacuo.

Workup

  1. filtrationThe solid is filtered off
  2. washwashed twice with 0.5 ml dioxane each time
  3. customsubsequently dried in vacuo

Sources & evidence

ORD record
ord-75df74eafbc140e1971cbc0b4af1270a
Source dataset
uspto-grants-2013_03
Patent number
US08389520B2

Reaction notes

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