HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tributylvinyltin → 5,7-Difluoro-6-vinyl-quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tributylvinyltin | HCID 81998 | — |
| Reactant | 6-Bromo-5,7-difluoroquinoline | HCID 45108354 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5,7-Difluoro-6-vinyl-quinoline | HCID 57917380 | — |
Reaction Conditions
| Temperature | 150 °C |
|---|
Reaction Steps
6-Bromo-5,7-difluoro-quinoline ((viii), 1 g, 4.10 mmol), tetrakis(triphenylphosphine)palladium (0) (47 mg, 0.041 mmol) and tributyl(vinyl)tin (1.34 g, 4.10 mmol) were put together with dioxane (3.7 mL) in a microwave reactor and stirred for 25 min at 150° C. under microwave irradiations. The solvent was removed and the residue was purified by MPLC with hexane and EtOAc. The title compound was obtained as a colorless oil (tR 1.1 min (conditions 4), MH+=192).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08389526B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-a7fb3cf8d1ac43b9b6c11e9da7215cc8 |
| Source note | uspto-grants-2013_03 |