1-Methylpiperazin-2-one--hydrogen chloride (1/1) → HCID 50915059, compound

HRID 1942086Notes

Reaction equation

HRID 1942086 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([CH2:11][C:12]3[CH:13]=[C:14]4[C:19](=[CH:20][C:21]=3[F:22])[N:18]=[CH:17][CH:16]=[CH:15]4)=[CH:9][N:10]=2)[N:7]=1.Cl.[CH3:24][N:25]1[CH2:30][CH2:29][NH:28][CH2:27][C:26]1=[O:31]>>[F:22][C:21]1[CH:20]=[C:19]2[C:14]([CH:15]=[CH:16][CH:17]=[N:18]2)=[CH:13][C:12]=1[CH2:11][C:8]1[N:6]2[N:7]=[C:2]([N:28]3[CH2:29][CH2:30][N:25]([CH3:24])[C:26](=[O:31])[CH2:27]3)[CH:3]=[CH:4][C:5]2=[N:10][CH:9]=1

Participants

3

Reactant 2

HCID 170607661-Methylpiperazin-2-one--hydrogen chloride (1/1)HCID 581475166-(6-Chloro-imidazo[1,2-b]pyridazin-3-ylmethyl)-7-fluoro-quinoline2×

Product 1

HCID 50915059HCID 50915059, compound

Procedure

The title compound was prepared in analogy to Example 38 using 6-(6-chloro-imidazo[1,2-b]pyridazin-3-ylmethyl)-7-fluoro-quinoline (Intermediate J, 50 mg, 0.160 mmol) and 1-methylpiperazin-2-one hydrochloride (36.5 mg, 0.320 mmol) (tR 3.11 min (conditions 5), MH+=391, 1H-NMR in DMSO-d6: 8.84 (d, 1H); 8.33 (d, 1H); 7.95 (s, 1H); 7.85 (d, 1H); 7.71 (d, 1H); 7.48 (m, 1H); 7.46 (s, 1H); 7.15 (d, 1H); 4.42 (s, 2H); 4.06 (s, 2H); 3.75 (m, 2H); 3.49 (m, 2H); 2.83 (m, 3H)).

Sources & evidence

ORD record
ord-83bb58a3a28d45eebc56e63e89ab0a7f
Source dataset
uspto-grants-2013_03
Patent number
US08389526B2

Reaction notes

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