1-Methylpiperazin-2-one--hydrogen chloride (1/1) → HCID 50915059, compound

Participants

Reaction Steps

The title compound was prepared in analogy to Example 38 using 6-(6-chloro-imidazo[1,2-b]pyridazin-3-ylmethyl)-7-fluoro-quinoline (Intermediate J, 50 mg, 0.160 mmol) and 1-methylpiperazin-2-one hydrochloride (36.5 mg, 0.320 mmol) (tR 3.11 min (conditions 5), MH+=391, 1H-NMR in DMSO-d6: 8.84 (d, 1H); 8.33 (d, 1H); 7.95 (s, 1H); 7.85 (d, 1H); 7.71 (d, 1H); 7.48 (m, 1H); 7.46 (s, 1H); 7.15 (d, 1H); 4.42 (s, 2H); 4.06 (s, 2H); 3.75 (m, 2H); 3.49 (m, 2H); 2.83 (m, 3H)).

Provenance & Evidence