1-Acetylpiperazine → HCID 50912874, compound

HRID 1942088Notes

Reaction equation

HRID 1942088 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([CH2:11][C:12]3[CH:13]=[C:14]4[C:19](=[CH:20][C:21]=3[F:22])[N:18]=[CH:17][CH:16]=[CH:15]4)=[CH:9][N:10]=2)[N:7]=1.[C:23]([N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1)(=[O:25])[CH3:24]>>[F:22][C:21]1[CH:20]=[C:19]2[C:14]([CH:15]=[CH:16][CH:17]=[N:18]2)=[CH:13][C:12]=1[CH2:11][C:8]1[N:6]2[N:7]=[C:2]([N:29]3[CH2:30][CH2:31][N:26]([C:23](=[O:25])[CH3:24])[CH2:27][CH2:28]3)[CH:3]=[CH:4][C:5]2=[N:10][CH:9]=1

Participants

3

Reactant 2

HCID 837951-AcetylpiperazineHCID 581475166-(6-Chloro-imidazo[1,2-b]pyridazin-3-ylmethyl)-7-fluoro-quinoline2×

Product 1

HCID 50912874HCID 50912874, compound

Procedure

The title compound was prepared in analogy to Example 38 using 6-(6-chloro-imidazo[1,2-b]pyridazin-3-ylmethyl)-7-fluoro-quinoline (Intermediate J, 50 mg, 0.160 mmol) and 1-acetylpiperazine (41.0 mg, 0.320 mmol) (tR 3.17 min (conditions 5), MH+=391, 1H-NMR in DMSO-d6: 8.85 (d, 1H); 8.33 (d, 1H); 7.94 (d, 1H); 7.84 (d, 1H); 7.74 (d, 1H); 7.46 (m, 1H); 7.44 (s, 1H); 7.14 (d, 1H); 4.40 (s, 2H); 3.48 (s, 6H); 3.42 (m, 2H); 2.00 (s, 3H)).

Sources & evidence

ORD record
ord-c650121748cc4978acf17dd7c5658446
Source dataset
uspto-grants-2013_03
Patent number
US08389526B2

Reaction notes

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